Transcriptomic analysis reveals novel long non-coding RNAs critical for vertebrate development [Illumina]

ABSTRACT: Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression and chromatin modifications, with important functions in development and disease. Here we sought to identify and functionally characterize lncRNAs critical for vascular vertebrate development with significant conservation across species. Genome-wide transcriptomic analyses during human vascular lineage specification enabled the identification of three conserved novel lncRNAs: TERMINATOR, ALIEN and PUNISHER that are specifically expressed in pluripotent stem cells, mesoderm and endothelial cells, respectively. Gene expression profiling, alongside RNA immunoprecipitation coupled to mass spectrometry, revealed a wide range of new molecular networks and protein interactors related to post-transcriptional modi

ORGANISM(S): Homo sapiens

SUBMITTER: Christopher Benner 

PROVIDER: E-GEOD-54966 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress