Transcriptional responses of Middle East respiratory syndrome coronavirus (MERS-CoV) in marmosets

ABSTRACT: The absence of a robust disease model currently hinders the evaluation of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV that results in mild-to-moderate disease has been utilized to describe the pathogenesis of this virus and for the evaluation of therapeutics, the inability to produce uniform disease with substantial virus replication complicates analysis in countermeasure studies. In an attempt to identify a more robust disease model, DPP4 sequences of various non-human primates were aligned. Modeling of the interactions between the receptor binding domain of MERS-CoV and its cognate receptor DPP4 predicted a "good fit" with complete conservation of all of the critical residues. To determine the feasibility

ORGANISM(S): Callithrix jacchus

SUBMITTER: Michael Katze 

PROVIDER: E-GEOD-55023 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress