MicroRNA-15/16 Antagonizes c-Myb to Control Natural Killer Cell Maturation

ABSTRACT: NK cells develop in the bone marrow and complete their maturation in peripheral organs, but the molecular events controlling maturation are incompletely understood. Utilizing an NK cell-specific miR-15/16 deficient genetic model (15aKO), we identified a critical role for miR-15/16 family microRNAs in the normal maturation of NK cells in vivo, with a specific reduction in mature CD11b+CD27- NK cells in multiple tissues. The mechanism responsible was a block in differentiation, since accelerated NK cell death was not evident, and earlier intermediates of NK cell maturation were expanded. Further, we identified Myb as a direct target of miR-15/16 in NK cells, with Myb expression increased in immature 15aKO NK cells. Following adoptive transfer, immature 15aKO NK cells exhibited defective matu

ORGANISM(S): Mus musculus

SUBMITTER: Todd Fehniger 

PROVIDER: E-GEOD-55033 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress