Oncogene-like induction of cellular invasion from centrosome amplification

ABSTRACT: Centrosome amplification has long been recognized as a feature of human tumors, however its role in tumorigenesis remains unclear. Centrosome amplification is poorly tolerated by non-transformed cells, and, in the absence of selection, extra centrosomes are spontaneously lost. Thus, the high frequency of centrosome amplification, particularly in more aggressive tumors, raises the possibility that extra centrosomes could, in some contexts, confer advantageous characteristics that promote tumor progression. Using a three-dimensional model system and other approaches to culture human mammary epithelial cells, we find that centrosome amplification triggers cell invasion. This invasive behavior is similar to that induced by overexpression of the breast cancer oncogene ErbB2 and indeed enhances

ORGANISM(S): Homo sapiens

SUBMITTER: Susana Godinho 

PROVIDER: E-GEOD-55042 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress