Expression data from isolated E16.5 mouse skin with or without Ovol2 overexpression

ABSTRACT: During epithelial tissue morphogenesis, developmental progenitor cells undergo dynamic adhesive and cytoskeletal remodeling to trigger proliferation and migration. Transcriptional mechanisms that restrict such mild form of epithelial plasticity to maintain lineage-restricted differentiation in committed epithelial tissues are poorly understood. Here we report that simultaneous ablation of transcriptional repressor-encoding Ovol1 and Ovol2 results in expansion and blocked terminal differentiation of embryonic epidermal progenitor cells. Conversely, mice overexpressing Ovol2 in their skin epithelia exhibit precocious differentiation accompanied by smaller progenitor cell compartments. We show that Ovol1/2-deficient epidermal cells fail to undertake alpha-catenin–driven actin cytoskeletal reo

ORGANISM(S): Mus musculus

SUBMITTER: Xing Dai 

PROVIDER: E-GEOD-55073 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress