Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression data from human subcutaneous adipose tissue

ABSTRACT: Obesity is a heterogeneous conditions comprising obese individuals with metabolic disorders (termed metabolically unhealthy obese; MUO) and obese individuals who are metabolically healthy (termed metabolically healthy obese; MHO). We used microarrays to examine differences in subcutaneous adipose tissue gene expression from lean healthy (LH), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO) individuals. Subcutaneous adipose tissue samples from the periumbilical region were obtained under local anesthesia and after an overnight fast. 50-100 mg of adipose tissue was homogenized and total RNA was extracted after homogenisation in TRIzol reagent using a tissue homogenizer.

ORGANISM(S): Homo sapiens

SUBMITTER: David Mutch 

PROVIDER: E-GEOD-55200 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese.

Badoud Flavia F   Lam Karen P KP   DiBattista Alicia A   Perreault Maude M   Zulyniak Michael A MA   Cattrysse Bradley B   Stephenson Susan S   Britz-McKibbin Philip P   Mutch David M DM  

Journal of proteome research 20140623 7

A subgroup of obese individuals, referred to as metabolically healthy obese (MHO), have preserved insulin sensitivity and a normal lipid profile despite being obese. The molecular basis for this improved cardiometabolic profile remains unclear. Our objective was to integrate metabolite and gene expression profiling to elucidate the molecular distinctions between MHO and metabolically unhealthy obese (MUO) phenotypes. A subset of individuals were selected from the Diabetes Risk Assessment study a  ...[more]

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