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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Effect of NDRG3 over-expression and knockdown on cell response to hypoxia

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Minho Kang

PROVIDER: E-GEOD-55214 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A lactate-induced response to hypoxia.

Lee Dong Chul DC Sohn Hyun Ahm HA Park Zee-Yong ZY Oh Sangho S Kang Yun Kyung YK Lee Kyoung-Min KM Kang Minho M Jang Ye Jin YJ Yang Suk-Jin SJ Hong Young Ki YK Noh Hanmi H Kim Jung-Ae JA Kim Dong Joon DJ Bae Kwang-Hee KH Kim Dong Min DM Chung Sang J SJ Yoo Hyang Sook HS Yu Dae-Yeul DY Park Kyung Chan KC Yeom Young Il YI

Cell 20150416 3

Organisms must be able to respond to low oxygen in a number of homeostatic and pathological contexts. Regulation of hypoxic responses via the hypoxia-inducible factor (HIF) is well established, but evidence indicates that other, HIF-independent mechanisms are also involved. Here, we report a hypoxic response that depends on the accumulation of lactate, a metabolite whose production increases in hypoxic conditions. We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normo ...[more]

PMID: 25892225

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Simultaneous analysis of tumor and stromal gene expression profiles from xenograft models

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