4C-seq: Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

ABSTRACT: Hox genes are essential regulators of embryonic development. They are activated in a temporal sequence following their topological order within their genomic clusters. Subsequently, states of activity are fine-tuned and maintained to translate into domains of progressively overlapping gene products. While the mechanisms underlying such temporal and spatial progressions begin to be understood, many of their aspects remain unclear. We have systematically analyzed the 3D chromatin organization of Hox clusters in vivo, during their activation using high-resolution circular chromosome conformation capture (4C-seq). Initially, Hox clusters are organized as single 3D chromatin compartments decorated with bivalent chromatin marks. Their progressive transcriptional activation is associated with a d

ORGANISM(S): Mus musculus

SUBMITTER: Marion LELEU 

PROVIDER: E-GEOD-55342 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress