BP001-002: The genomic landscape of compensatory evolution

ABSTRACT: Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, deleterious mutations may also have an important role by promoting adaptive genetic changes that are otherwise inaccessible. Here we study the capacity of the bakerM-bM-^@M-^Ys yeast genome to compensate the complete loss of genes during evolution, and explore the long-term consequences of this process. We initiated laboratory evolutionary experiments with over 180 haploid yeast genotypes, all of which initially displayed slow growth due to the deletion of a single gene. Compensatory adaptation was rapid and pervasive, and it promoted the genomic divergence of parallel evolving populations. The accumulated mutations did not restore wild type genomic expression states and generated

ORGANISM(S): Saccharomyces cerevisiae BY4741

SUBMITTER: Marian Groot Koerkamp 

PROVIDER: E-GEOD-55373 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress