Local modulation of DNA replication controls

ABSTRACT: Background: Eukaryotic cells must inhibit re-initiation of DNA replication at each of the thousands of origins in their genome because re-initiation events can generate genomic alterations with extraordinary frequency. To minimize the probability of re-initiation from so many origins, cells use a battery of regulatory mechanisms that reduce the activity of replication initiation proteins. Given the global nature of these mechanisms, it has been presumed that all origins are inhibited identically. However, transiently disabling these mechanisms causes replication origins to re-initiate with diverse efficiencies, which do not correlate with known differences in the efficiency or timing of origin initiation during normal DNA replication. These observations suggest an additional local laye

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Joachim Li 

PROVIDER: E-GEOD-55420 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress