Gene expression profile of calcified and normal tricuspid aortic valves by RNA sequencing.

ABSTRACT: Purpose: Calcific aortic valve stenosis (AS) is a fatal disease with currently no medical therapy. Some genes were associated with AS, but the genetic architecture of the disease has yet to be discovered. The objective of this study was to combine genome-wide association studies (GWAS) and gene expression in human valve tissues to identify new susceptibility genes of AS. Methods: A meta-analysis was performed combining the results of two independent GWAS in 474 patients that underwent aortic valve replacement from Quebec city and 486 echocardiography cases from France. The controls consisted of 3,151 publically available individuals of European ancestry. Sixty-nine SNPs selected from the meta-analysis (p < 1 x 10-4) were followed-up for replication in a third cohort of 395 cases and 404 co

ORGANISM(S): Homo sapiens

SUBMITTER: Sandra Guauque-Olarte 

PROVIDER: E-GEOD-55492 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress