Transcription profiling of human CD43+ cells from chronic-phase untreated CML patients vs controls to determine a molecular signature

ABSTRACT: Comparison of gene expression profiles of CD34+ hematopoietic stem and progenitor cells from bone marrow of patients with untreated chronic myelogenous leukemia (CML) in chronic phase with those from bone marrow of healthy volunteers. Chronic myelogenous leukaemia (CML) is a malignant disorder of the hematopoietic stem cell, which is characterized by the reciprocal translocation between chromosomes 9 and 22 (t(9;22)(q34;q11)) The translocation results in the formation of the BCR-ABL fusion oncogene encoding a protein with constitutive activated tyrosine kinase activity which plays a central role in the pathogenesis of the disease. There are still several open questions with respect to BCR-ABL-induced malignant transformation. A large limitation of the existing data about BCR-ABL effects is

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Michael Rosskopf 

PROVIDER: E-GEOD-5550 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress