Domains of genomewide gene expression dysregulation in Down syndrome [RRBS]

ABSTRACT: Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we show that the differential expression between the twins is organized in domains along all chromosomes that are either up- or downregulated. These gene expression dysregulation domains (GEDDs) can be defined by the expression level of their gene content, and are well conserved in induced pluripotent stem cells derived from the twins’ fibroblasts. Comparison of the transcriptome of the Ts65Dn mouse model of DS and wild-type, also showed GEDDs along the mouse chromosomes that were syntenic in human.

ORGANISM(S): Homo sapiens

SUBMITTER: Audrey Letourneau 

PROVIDER: E-GEOD-55505 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress