Implications of the miR-10 family in chemotherapy response of NPM1 mutated AML

ABSTRACT: Nucleophosmin mutated AML (NPM1mut-AML) patients have a high rate of complete remission (CR) to induction chemotherapy. However, the mechanisms responsible for such effects are unknown. Since miR-10 family members are expressed at high levels in NPM1mut-AML, we evaluated whether these microRNAs could predict chemotherapy response in AML. We found that high baseline miR-10 family expression in 54 untreated cytogenetically heterogeneous AML patients was associated with achieving CR. However, when we included NPM1 mutation status in the multivariable model, there was a significant interaction effect between miR-10a-5p expression and NPM1 mutation status. Similar results were observed when using a second cohort of 183 cytogenetically normal older (ageM-bM-^IM-%60 years) AML patients. Loss and

ORGANISM(S): Homo sapiens

SUBMITTER: Ramiro Garzon 

PROVIDER: E-GEOD-55519 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress