Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mats Ljungman
PROVIDER: E-GEOD-55534 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Genome research 20140408 6
The rate of transcription elongation plays an important role in the timing of expression of full-length transcripts as well as in the regulation of alternative splicing. In this study, we coupled Bru-seq technology with 5,6-dichlorobenzimidazole 1-β-D-ribofuranoside (DRB) to estimate the elongation rates of over 2000 individual genes in human cells. This technique, BruDRB-seq, revealed gene-specific differences in elongation rates with a median rate of around 1.5 kb/min. We found that genes with ...[more]