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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Deregulated Myc Requires MondoA for Metabolic Reprogramming and Tumorigenesis

ABSTRACT: In order to investigate the effect of MondoA loss on the expression of Myc-dependent genes, we performed a microarray analysis from RNAs isolated from TET21N cells expressing either control (siControl) or MondoA (siMondoA) siRNAs either with (NT) or without (Doxy) induced N-Myc expression. TET21N cells were grown in medium with either Doxy (Myc-Off) or No Treatment (Myc-On), then transiently transfected with either non-specific siRNA or MondoA siRNA in replicates. Cells were then lysed and RNA isolated.

ORGANISM(S): Homo sapiens

SUBMITTER: Lisa McFerrin

PROVIDER: E-GEOD-55538 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deregulated Myc Requires MondoA for Metabolic Reprogramming and Tumorigenesis

Project description:In order to investigate the effect of MondoA loss on the expression of Myc-dependent genes, we performed a microarray analysis from RNAs isolated from TET21N cells expressing either control (siControl) or MondoA (siMondoA) siRNAs either with (NT) or without (Doxy) induced N-Myc expression.

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MondoA Drives Malignancy in B-ALL through Enhanced Adaptation to Metabolic Stress [array]

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Gene expression data from human ovarian cancer cells treated with siRNAs targeting CPNE8 and BHLHE41

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Survival of cells with deregulated MYC requires UVSSA-dependent regulation of RNAPII dynamics

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