Pseudomonas aeruginosa lasR mutants in young cystic fibrosis patients

ABSTRACT: Pseudomonas aeruginosa undergoes genetic change during chronic infection of the airways of cystic fibrosis (CF) patients. One common change is mutation of lasR. LasR is a transcriptional regulator that responds to one of the quorum sensing signals in P. aeruginosa, and regulates acute virulence factor expression as well as central metabolic functions. P. aeruginosa mutants in which lasR was inactivated emerged in the airways of CF patients early during chronic infection, and during growth in the laboratory on Luria-Bertani agar. Both environments are rich in amino acids. Inactivation of lasR in these isolates conferred a growth advantage with amino acids, a phenotype that could account for selection of lasR mutants both in vivo and in vitro. P. aeruginosa lasR mutants were identified

ORGANISM(S): Pseudomonas aeruginosa

SUBMITTER: David Dargenio 

PROVIDER: E-GEOD-5560 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress