Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury

ABSTRACT: Molecular profiling of infiltrating monocyte-derived macrophages versus resident kupffer cells following acute liver injury The liver has a remarkable capacity to regenerate after injury; yet, the role of macrophages (MF) in this process remains controversial mainly due to difficulties in distinguishing between different MF-subsets. Here, we utilized a murine model of acute liver injury caused by overdose of acetaminophen (APAP) and defined three distinct MF subsets that populate the liver following injury. Accordingly, resident Kupffer cells (KC) were significantly reduced upon APAP-challenge and started recovering by self-renewal at resolution phase without contribution of circulating Ly6Chi monocytes. The latter were recruited in a CCR2 and M-CSF mediated pathway at the necro-inflammato

ORGANISM(S): Mus musculus

SUBMITTER: Metsada Pasmanik-Chor 

PROVIDER: E-GEOD-55606 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress