Unbiased Capture Hi-C reveals the potential targets of breast cancer susceptibility loci

ABSTRACT: Genome-wide association studies have identified over 70 common variants that are associated with breast cancer risk. Most of these variants map to non-protein-coding regions; several map to gene deserts, regions of several hundred kb lacking protein-coding genes. We hypothesized that gene deserts harbour long-range regulatory elements that can physically interact with target genes to influence their expression. To test this, we developed Capture Hi-C (CHi-C), which by incorporating a sequence capture step into a Hi-C protocol, allows high-resolution analysis of targeted regions of the genome. We used CHi-C to investigate long-range interactions at three breast cancer gene deserts mapping to 2q35, 8q24.21 and 9q31.2. We identified interaction peaks between putative regulatory elements (&quo

ORGANISM(S): Homo sapiens

SUBMITTER: Nicola Dryden 

PROVIDER: E-GEOD-55634 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress