Existence of conventional dendritic cells in Gallus gallus revealed by comparative gene expression profiling

ABSTRACT: The existence of conventional dendritic cells (cDCs) has not yet been demonstrated outside mammals. In this paper, we identified bona fide cDCs in chicken spleen. Comparative profiling of global and of immune response gene expression, morphology, and T cell activation properties show that cDCs and macrophages (MPs) exist as distinct mononuclear phagocytes in chicken, resembling their human and mouse cell counterparts. Using computational analysis, core gene expression signatures for cDCs, MPs, T and B cells across chicken, human and mouse were established, which will facilitate the identification of these subsets in other vertebrates. Overall this study, by extending the newly uncovered cDC and MP paradigm to chicken, suggests that the generation of these two phagocyte lineages occurred be

ORGANISM(S): Gallus gallus

SUBMITTER: pierre Sibille 

PROVIDER: E-GEOD-55642 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress