Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Robert Ivanek 

PROVIDER: E-GEOD-55711 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition.

Diepenbruck Maren M   Waldmeier Lorenz L   Ivanek Robert R   Berninger Philipp P   Arnold Phil P   van Nimwegen Erik E   Christofori Gerhard G  

Journal of cell science 20140219 Pt 7


The cellular changes during an epithelial-mesenchymal transition (EMT) largely rely on global changes in gene expression orchestrated by transcription factors. Tead transcription factors and their transcriptional co-activators Yap and Taz have been previously implicated in promoting an EMT; however, their direct transcriptional target genes and their functional role during EMT have remained elusive. We have uncovered a previously unanticipated role of the transcription factor Tead2 during EMT. D  ...[more]

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