Effect of lymphotoxin beta receptor blockade on microRNA expression in the spleen [ExiqonMicroRNA]

ABSTRACT: Follicular dendritic cells (FDC) are important stromal cells within the B cell follicles and germinal centres (GC) of secondary lymphoid tissues. FDC trap and retain native antigens on their surfaces in the form of immune complexes which they display to B cells, in order to select those cells with the highest antigen affinity. MicroRNAs are short, non-coding RNAs of approximately 18-25 nucleotides in length that regulate gene expression at the post-transcriptional level by repressing the translation of target genes. In the current study in vivo and in vitro systems were used to identify microRNAs that are differentially expressed as a result of FDC depletion. Constitutive lymphotoxin-M-NM-2 receptor (LTM-NM-2R) stimulation is required to maintain FDC in their differentiated state. We

ORGANISM(S): Mus musculus

SUBMITTER: Neil Mabbott 

PROVIDER: E-GEOD-55721 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress