Expression data from chemically-induced skin papillomas (benign tumours)

ABSTRACT: Cancer stem cells (CSCs) have been reported in various cancers including skin squamous cell carcinoma (SCC). The molecular mechanisms regulating tumour initiation and stemness are still poorly characterized. Here, we found that Sox2, a transcription factor expressed in various types of embryonic and adult stem cells (SCs), was the most upregulated transcription factor in CSCs of squamous skin tumours. Sox2 is absent in normal epidermis and begins to be expressed in the vast majority of mouse and human pre-neoplastic skin tumours and continues to be expressed in a heterogeneous manner in invasive mouse and human SCCs. In contrast to other SCCs, in which Sox2 is frequently genetically amplified, the expression of Sox2 in mouse and human skin SCCs is transcriptionally regulated. Conditional d

ORGANISM(S): Mus musculus

SUBMITTER: CM-CM-)dric BLANPAIN 

PROVIDER: E-GEOD-55738 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress