Transcriptional profiling of liver from wild type and PXR-null mice treated with PCN

ABSTRACT: Many environmentally-relevant chemicals and drugs activate the nuclear receptor pregnane X receptor (PXR). Activation of PXR can lead to increases in liver weight in part through hepatocyte replication similar to a large number of compounds that activate other nuclear receptors such as the peroxisome proliferator-activated receptor alpha and the constitutive activated receptor (CAR). PXR controls the expression of a large battery of genes involved in xenobiotic metabolism. Identification of genes that are accurate predictors of PXR activation would be useful in high-throughput screens to assess potential toxicity and drug-drug interactions. Here, we identified PXR-dependent genes in the mouse liver after exposure to pregnenolone 16alpha-carbinonitrile (PCN), a chemical that is often us

ORGANISM(S): Mus musculus

SUBMITTER: J Corton 

PROVIDER: E-GEOD-55746 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress