Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer

ABSTRACT: Human colorectal cancer (CRC) cell lines are a used widely-used to model system for investigation investigate of tumour biology, experimental therapytherapeutic and biomarkers discovery. However, to what extent these established CRC cell lines represent and maintain the genetic diversity of primary cancers is uncertain. In this study, we analyzed 70 CRC cell lines were analysed for mutations using whole exome sequencing and DNA copy-number using by whole-exome sequencing and SNP microarray profilings, respectively. Presence of gGene expression was defined using RNA-Seq. Data from cellCell line datas were was compared to those that published from for primary CRCs published by in The the Cancer Genome Atlas Network. Notably, we found that The spectrum of exome mutations and DNA copy-number a

ORGANISM(S): Homo sapiens

SUBMITTER: Oliver Sieber 

PROVIDER: E-GEOD-55832 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress