VHL Status Influences Phenotype of Liver Cancers Arising from PTEN Loss

ABSTRACT: Background: PTEN loss contributes to the development of many cancers and is associated with both hepatocellular carcinoma and cholangiocarcinoma. The pathogenesis of these malignancies is unclear, but they are speculated to arise from common cellular origins. We explored the influence of secondary effects, like hypoxia signaling, through co-deletion of Pten and Vhl in a murine model.Methods: We used a CreER-linked keratin 18 mouse model to conditionally delete Pten, Vhl or both, evaluating the resultant tumors by histology and gene expression microarray. A cohort of human cholangiocarcinoma samples was evaluated for relationships between HIF-1a expression and clinical outcomes.Results: Both Pten deletion genotypes developed liver tumors, but with differing phenotypes. Pten deletion alone l

ORGANISM(S): Mus musculus

SUBMITTER: Kimryn Rathmell 

PROVIDER: E-GEOD-55874 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress