Gene Expression profiles of colon from Hif-1α+/+, Hif-1αLSL/LSL

ABSTRACT: To investigate the detailed molecular mechanisms for the regulatory role of HIF-1α in colon, microarray gene expression analysis was performed on colon RNA isolated from 6- to 8-week-old Hif-1α+/+, Hif-1αLSL/LSL mice. Background & Aims: The progression and growth of solid tumors leads to a state where tumors outgrow their capacity for efficient oxygenation and nutrient uptake and an increase in tumor hypoxia. Tumor hypoxic response is mediated by hypoxia-inducible factor (HIF)-1a and HIF-2a. These transcription factors regulate a battery of genes that are critical for tumor oxygenation, tumor metabolism, and cell proliferation and survival. Therefore, inhibitors of HIF have been sought for as anti-neoplastic agents in several different kinds of cancers. Interestingly, in ischemic and infl

ORGANISM(S): Mus musculus

SUBMITTER: XIANG XUE 

PROVIDER: E-GEOD-55915 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress