Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Expression profiling of 143B-shCtrl and 143B-shIRX1 stable osteosarcoma cell lines

ABSTRACT: Pulmonary metastasis is the main cause of medical failure and death of osteosarcoma patients. Our recent study identified IRX1 as a potential metastasis-driving gene in osteosarcoma. Studies showed that IRX1 can promote the migration, invasion and anoikis resistance of osteosarcoma cells. We generated 143B stable IRX1 knockdown and control cell lines, and found that IRX1 knockdown can inhibit the pulmonary metastasis of 143B cells in orthotopic mouse osteosarcoma model. Expression microarrays are performed in143B-shCtrl and 143B-shIRX1 cells to study the mechanism of IRX1 on promoting metastasis of osteosarcoma

ORGANISM(S): Homo sapiens

SUBMITTER: Jinchang Lu 

PROVIDER: E-GEOD-55958 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling.

Lu Jinchang J   Song Guohui G   Tang Qinglian Q   Zou Changye C   Han Feng F   Zhao Zhiqiang Z   Yong Bicheng B   Yin Junqiang J   Xu Huaiyuan H   Xie Xianbiao X   Kang Tiebang T   Lam YingLee Y   Yang Huiling H   Shen Jingnan J   Wang Jin J  

The Journal of clinical investigation 20150330 5

Osteosarcoma is a common malignant bone tumor with a propensity to metastasize to the lungs. Epigenetic abnormalities have been demonstrated to underlie osteosarcoma development; however, the epigenetic mechanisms that are involved in metastasis are not yet clear. Here, we analyzed 2 syngeneic primary human osteosarcoma cell lines that exhibit disparate metastatic potential for differences in epigenetic modifications and expression. Using methylated DNA immunoprecipitation (MeDIP) and microarray  ...[more]

Similar Datasets

Unknown Expression profiling of 143B-shCtrl and 143B-shIRX1 stable osteosarcoma cell lines
2015-08-25 | GSE55958 | GEO
Transcriptomics Expression profiling of HCT116 cells transfected with shCTRL or shKSR1
2015-01-28 | E-GEOD-65351 | biostudies-arrayexpress
Transcriptomics Expression data from shlncTCF7 and shCtrl of hepatocellular carcinoma (HCC) clinical sample
2015-03-05 | E-GEOD-66515 | biostudies-arrayexpress
Genomics,Multiomics Homo sapiens
| PRJNA241435 | ENA
Unknown RNA sequencing to determine gene expression changes in Siglec-15 knockdown oteosarcoma cells
2021-05-25 | GSE175414 | GEO
Unknown Transcriptomic analysis of SiHa cells stably expressing shCtrl or shSYT7
2022-04-11 | GSE200526 | GEO
Unknown Gene regulation by m6A demethylase ALKBH5 in osteosarcoma [RNA-seq]
2022-06-28 | GSE154528 | GEO
Unknown Expression data of shDIDO1 and shCtrl HUVEC cell lines
2022-01-07 | GSE156713 | GEO
Transcriptomics Gene expression profiles from osteosarcpma samples
2010-02-22 | E-GEOD-14827 | biostudies-arrayexpress
Proteomics Quantitative proteomic analysis of mouse cerebellar granule cells after knockdown of YTHDF1
2022-02-15 | PXD019249 | Pride