Characterization of transcriptome dynamics in response to contact with host cells [Phase I In Vitro]

ABSTRACT: Candida albicans is the major invasive fungal pathogen of humans, causing diseases ranging from superficial mucosal infections to disseminated, systemic infections which are often life threatening. Hematogenously disseminated candidiasis (HDC) has a 47% mortality rate despite current antifungal therapy. An increase in prevalence, as well as an increasing resistance to most of the clinically important antifungal therapies, provides a strong impetus to understand the molecular mechanisms of pathogenesis and the acquisition of drug resistance. This information holds promise to identify novel therapeutic targets. A complete and accurate characterization of how the transcriptome of C. albicans responds to its interaction with cells from the host is an absolute necessity to accomplish this goal.

ORGANISM(S): Candida albicans

SUBMITTER: Amol Shetty 

PROVIDER: E-GEOD-56091 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress