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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression Array analysis of MTAP in HT080 cells

ABSTRACT: Methylthioadenosine Phosphorylase (MTAP) is a tumor suppressor gene that encodes an enzyme responsible for the catabolism of the polyamine byproduct 5′deoxy-5′-methylthioadenosine (MTA). To elucidate the mechanism by which MTAP inhibits tumor formation, we have created isogenic MTAP+ and MTAP- HT1080 fibrosarcoma cells. In this experiment we have performed expression array analysis on MTAP-, MTAP+, and MTAP+ cells treated with the MTAP inhibitor MT-DADMe-ImmA. Three biological replicates of each sample were grown and analyzed. M- is MTAP-. M+ is MTAP+, and M+I is MTAP treated with inhibitor (48 hours).

ORGANISM(S): Homo sapiens

SUBMITTER: warren kruger

PROVIDER: E-GEOD-56112 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression Array analysis of MTAP in HT080 cells

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