Analyses the expression profile of hsp31∆, hsp32∆, hsp33∆ during diauxic shift

ABSTRACT: The yeast Hsp31 mini-family proteins (Hsp31, Hsp32, Hsp33, Hsp34) belong to the highly conserved DJ-1 superfamily. The human DJ-1 protein is associated with cancer and neurodegenerative disorders, such as Parkinson’s disease. However, the precise function of human and yeast DJ-1 proteins is unclear. Here we show that the yeast DJ-1 homologs have a role in diauxic-shift, characterized by metabolic reprogramming due to glucose limitation. We find that the Hsp31 genes are strongly induced in diauxic-shift and in stationary phase (SP), and that deletion of these genes reduces chronological lifespan, impairs transcriptional reprogramming at diauxic-shift, and impairs the acquisition of several typical characteristics of SP, including autophagy induction. In addition, under carbon starvation, th

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Leonor Miller-Fleming 

PROVIDER: E-GEOD-56124 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress