Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

CD8 CDKN2A-/- lymphocytes expressing an active form of the transcription factor Stat5

ABSTRACT: Transcriptome analyses of memory CDKN2A-/- CD8 T lymphocytes expressing an active form of the transcription factor Stat5. CDKN2A-/- CD8 T lymphocytes were activated by anti-CD3/CD28. After 40h, an active form of Stat5 was introduced in activated cells. Culture was continued for another 48h to induce their differentiation in effector T cells. These 88h activated T cells were injected in congeneic hosts and recovered 15 days later from the host spleen and lymph nodes: CDKN2A-/- Stat5ca -d15: 2 replicates– S46, S47. This study is a complement of the samples previously deposited under accession number GSE41819. Those two new samples are compared to previously deposited: - activated CD8 T lymphocytes transduced to express Stat5ca and transferred in congenic hosts: o S11 (GSM663446); o S12 (GSM663445); o S13 (GSM663444); o S14 (GSM663439). and - naive peripheral CD8 T lymphocytes : o S33 (GSM663441); o S34 (GSM663435); o S35 (GSM663449); o S36 (GSM663447).

ORGANISM(S): Mus musculus

SUBMITTER: Nathalie AUPHAN-ANEZIN 

PROVIDER: E-GEOD-56154 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B.

Grange Magali M   Giordano Marilyn M   Mas Amandine A   Roncagalli Romain R   Firaguay Guylène G   Nunes Jacques A JA   Ghysdael Jacques J   Schmitt-Verhulst Anne-Marie AM   Auphan-Anezin Nathalie N  

Immunology 20150615 4

CD8 T cells used in adoptive immunotherapy may be manipulated to optimize their effector functions, tissue-migratory properties and long-term replicative potential. We reported that antigen-stimulated CD8 T cells transduced to express an active form of the transcription factor signal transducer and activator of transcription 5 (STAT5CA) maintained these properties upon adoptive transfer. We now report on the requirements of STAT5CA-expressing CD8 T cells for cell survival and proliferation in vi  ...[more]

Similar Datasets

Transcriptomics Optimized CD8 effector TL
2013-09-13 | E-GEOD-26945 | biostudies-arrayexpress
Transcriptomics CD8 CDKN2A-/- lymphocytes expressing an active form of the transcription factor Stat5
2015-05-04 | GSE56154 | GEO
Genomics Active STAT5 in CD8 T cells imprints a T-Bet-dependent Tc-1 program with repressed IL-6/ TGFb1 signaling leading to enhanced anti-tumor responses
2013-09-13 | E-GEOD-41818 | biostudies-arrayexpress
Genomics,Multiomics Mus musculus
| PRJNA242561 | ENA
Transcriptomics Athsq1 is linked to Cdkn2a
2011-09-30 | E-GEOD-24342 | biostudies-arrayexpress
Transcriptomics Optimized CD8 effector TL
2013-09-13 | GSE26945 | GEO
Transcriptomics Gene expression data from Zeb2WT, Zeb2KO, T-betWT and T-betKO effector CD8+ T cells during infection
2015-09-19 | E-GEOD-72162 | biostudies-arrayexpress
Transcriptomics Athsq1 is linked to Cdkn2a
2011-10-01 | GSE24342 | GEO
Methylation profiling Epigenome analysis of human gastroesophageal junction (GEJ) organoids TP53/CDKN2A KO
2022-11-02 | GSE216814 | GEO
Transcriptomics Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function (RNA)
2012-04-24 | E-GEOD-36888 | biostudies-arrayexpress