Gene expression analysis of hair cell regeneration in the zebrafish lateral line

ABSTRACT: Deafness due to the terminal loss of inner ear hair cells is one of the most common sensory diseases. However, non-mammalian animals (e.g. birds, amphibian and fish) regenerate damaged hair cells. In order to better understand the reasons underpinning such regeneration disparities in vertebrates, we set out to define the changes in gene expression associated with the regeneration of hair cells in the zebrafish lateral line at high resolution. We performed RNA-Seq analyses on regenerating support cells purified by fluorescence activated cell sorting (FACS). The zebrafish lateral line provides an experimentally accessible system to define the complex signaling events triggered by injury and regeneration, because these cells can be acutely killed by exposure to neomycin, after which they rege

ORGANISM(S): Danio rerio

SUBMITTER: Chris Seidel 

PROVIDER: E-GEOD-56176 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress