Metabolism of sialic acid by Bifidobacterium breve UCC2003

ABSTRACT: Bifidobacteria constitute a specific group of commensal bacteria which inhabit the gastrointestinal tract of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilise several plant-derived carbohydrates that include cellodextrins, starch and galactan. In the current study, we investigate the ability of this strain to utilise the mucin- and human milk oligosaccharide (HMO)-derived carbohydrate, sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3’ sialyllactose, a HMO, by Bifidobacterium bifidum PRL2010. DNA-microarrays containing

ORGANISM(S): Bifidobacterium breve UCC2003

SUBMITTER: Mary O'Connell Motherway 

PROVIDER: E-GEOD-56291 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress