Distinctive Profile of IsomiR Expression and Novel MicroRNAs in Rat Heart Left Ventricle

ABSTRACT: MicroRNAs (miRNAs) are single-stranded non-coding RNAs that negatively regulate target gene expression through mRNA cleavage or translational repression. There is mounting evidence that they play critical roles in heart disease. The expression of known miRNAs in the heart has been studied at length by microarray and quantitative PCR but it is becoming evident that microRNA isoforms (isomiRs) are potentially physiologically important. It is well known that left ventricular (patho)physiology is influenced by transmural heterogeneity of cardiomyocyte phenotype, and this likely reflects underlying heterogeneity of gene expression. Given the significant role of miRNAs in regulating gene expression, knowledge of how the miRNA profile varies across the ventricular wall will be crucial to better u

ORGANISM(S): Rattus norvegicus

SUBMITTER: Anthony Collins 

PROVIDER: E-GEOD-56300 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress