Intratracheally Instilled Titanium Dioxide Nanoparticles Translocate to Heart and liver and Activate Complement Cascade in the Heart of C57BL/6 Mice (Liver)

ABSTRACT: An estimated 1% or less of the nanoparticles (NPs) deposited in lungs translocate to systemic circulation and enter other organs; however this estimation may not be accurate considering the low sensitivity of the existing in vivo NP detection methods. Moreover, the biological outcomes of such low levels of translocation are not elucidated. The objectives of the present study were to employ a Nano-scale Hyperspectral Microscope to spatially observe and spectrally profile NPs in tissues, and characterize the effects of NPs in blood, liver and heart following pulmonary deposition and subsequent translocation from lungs. Adult female C57BL/6 mice were exposed via intratracheal instillation to 18 and 162 µg per mouse of industrially relevant non-doped titanium dioxide nanoparticles (nano-TiO2).

ORGANISM(S): Mus musculus

SUBMITTER: Mainul Husain 

PROVIDER: E-GEOD-56325 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress