A PBMC Transcriptional Module Related to Vascular Function

ABSTRACT: Peripheral blood mononuclear cells (PBMCs), including rare circulating stem and progenitor cells (CSPCs), have important yet poorly understood roles in the maintenance and repair of blood vessels and perfused organs. Our hypothesis was that the identities and functions of CSPCs in cardiovascular health could be ascertained by analyzing the patterns of their co-expressed markers in unselected PBMC samples. Because gene microarrays had failed to detect many stem cell-associated genes, we performed quantitative real-time PCR to measure the expression of 45 primitive and tissue differentiation markers in PBMCs from healthy and hypertensive human subjects. We compared these expression levels to the subjects’ demographic and cardiovascular risk factors, including vascular stiffness. The tested m

ORGANISM(S): Homo sapiens

SUBMITTER: Leni Moldovan 

PROVIDER: E-GEOD-56327 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress