Memory CD8+ T cells induce precocious effector differentiation of naive T cells through quorum sensing-like behavior

ABSTRACT: Some unicellular organisms exhibit collective decision-making through intercellular communication once a quorum of members sense an environmental stress. Whether T cells at different states of differentiation may also synchronize their behavior on a population basis through direct interactions remains unclear. We report that memory CD8+ T cells (TMem) directly interact with naive T cells (TN) during priming, affecting the phenotypic, functional, transcriptional and metabolic differentiation of TN-derived progeny. This previously unrecognized, contact and concentration-dependent interaction between naive (TN) and memory CD8+ T cells (TMem) directly enhanced TN effector differentiation through non-apoptotic Fas signaling resulting in downstream Akt pathway activation. TN primed with TMem exh

ORGANISM(S): Mus musculus

SUBMITTER: Francesco Marincola 

PROVIDER: E-GEOD-56344 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress