Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer

ABSTRACT: We analyzed transcriptional changes in 4 prostate cancer cell lines following treatment with the BET inhibitor I-BET762 using Affymetrix Human Genome U133 Plus 2.0 Arrays. Four prostate cancer cell lines (NCI-H660, VCaP, LNCaP, PC-3) were treated with DMSO (control) or I-BET762 at 0.5uM or 10uM concentrations for 24 hours. Two biological replicates are included for each treatment group.

ORGANISM(S): Homo sapiens

SUBMITTER: Yuchen Bai 

PROVIDER: E-GEOD-56352 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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BET (bromodomain and extra-terminal) proteins regulate gene expression through their ability to bind to acetylated chromatin and subsequently activate RNA PolII-driven transcriptional elongation. Small molecule BET inhibitors prevent binding of BET proteins to acetylated histones and inhibit transcriptional activation of BET target genes. BET inhibitors attenuate cell growth and survival in several hematologic cancer models, partially through the down-regulation of the critical oncogene, MYC. We  ...[more]

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