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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Toxic effects of BDE209 in human embryonic kidney 293 cells (HEK 293)

ABSTRACT: PBDEs are widely used in consumer and household products as flame retardants. Many studies have shown that PBDEs could disrupt thyroid hormone homeostasis and adversely affect brain development. Here, we explored the toxical effects of BDE209 on HEK 293 cells and found that BDE209 may have a role in nucleosome remodeling. Many gene sets involved in cancer are enriched at the BDE209-treated sample. This indicates the carcinogenicity of BDE209. Interestingly, the impacts of BDE209 dissoved in DMSO on gene expression are more pronounced than the simple additive effects of BDE209 and DMSO alone. Gene expression profiles of human embryonic kidney 293 cells (HEK 293) cultured in normal medium, and medium containing BDE209 or DMSO were generated by deep sequencing, using Illumina HighSeq2000, respectively..

ORGANISM(S): Homo sapiens

SUBMITTER: Min Li

PROVIDER: E-GEOD-56361 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Toxic effects of BDE209 in human embryonic kidney 293 cells (HEK 293)

Project description:PBDEs are widely used in consumer and household products as flame retardants. Many studies have shown that PBDEs could disrupt thyroid hormone homeostasis and adversely affect brain development. Here, we explored the toxical effects of BDE209 on HEK 293 cells and found that BDE209 may have a role in nucleosome remodeling. Many gene sets involved in cancer are enriched at the BDE209-treated sample. This indicates the carcinogenicity of BDE209. Interestingly, the impacts of BDE209 dissoved in DMSO on gene expression are more pronounced than the simple additive effects of BDE209 and DMSO alone.

2014-04-21 | GSE56361 | GEO

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2014-10-10 | E-MTAB-1959 | biostudies-arrayexpress

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BPA impacts on HEK 293 cells

Project description:BPA impacts on HEK 293 cells

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Project description:HEK 293 cells were transiently transfected with plasmids expressing Vector only(PCMV), Aire, or MBD-VP16 with the goal of comparing the global gene expression profiles in the Aire and MBD-VP16 groups We used microarrays to detail the global gene expression profile. HEK 293 cells were transiently transfected with plasmids expressing Vector only(PCMV), Aire, or MBD-VP16 and 72 hrs post transfection total RNA was collected for microarray analysis.

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Project description:Homo sapiens strain:HEK 293 Raw sequence reads

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HEK-293 cells: Control cells transfected with hRIZ2 and rRIZ1

Project description:In order to evaluate the effects of RIZ2 overexpression on gene expression, a pilot expression study was performed through microarrays analysis. We compared the differential gene expression between HEK-293 cells overexpressing human RIZ2 (pEGFP-hRIZ2) and rat RIZ1 (pEGFP-rRIZ1) versus control cells transfected with the E-GFP empty vector alone (pEGFP).

2020-12-09 | GSE150031 | GEO

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