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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Novel type of EATL evolving from mucosal M-NM-3M-NM-4-T-cells in a RCD type I patient

ABSTRACT: Enteropathy associated T-cell lymphoma (EATL) is a rare non-Hodgkin lymphoma that may complicate celiac disease and typically occurs in patients with refractoriness to the gluten- free diet. The majority of these patients harbor intra-epithelial lymphocytes (IEL) with an aberrant phenotype in the small intestine which are thus considered as the M-bM-^@M-^XprecursorM-bM-^@M-^Y lymphoma cells. We here report on a case of extra-intestinal EATL that originated from a clonal M-NM-3M-NM-4-IEL population rather than from aberrant IEL. This EATL displayed a distinctive pattern of immunophenotypical, T-cell receptor immunogenetic, and chromosomal aberrancies defining this lymphoma as a novel variant of EATL. sample vs reference

ORGANISM(S): Homo sapiens

SUBMITTER: Daoud Sie

PROVIDER: E-GEOD-56425 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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