HIV-specific B cells are enriched within abnormal memory subsets in infected individuals

ABSTRACT: Recently, several neutralizing anti-HIV antibodies have been isolated from memory B cells of HIV-infected individuals. However, despite extensive evidence of B-cell dysfunction in HIV disease, little is known about the cells from which these rare HIV-specific antibodies originate. Accordingly, HIV envelope gp140 and CD4 or co-receptor (CoR) binding site (bs) mutant probes were used to evaluate HIV-specific responses in the peripheral blood B cells of individuals at various stages of infection. In contrast to non-HIV responses, HIV-specific responses against gp140 were enriched within abnormal B cells, namely activated and exhausted memory subsets, which are largely absent in the blood of uninfected individuals. Responses against the CoRbs (a poorly-neutralizing epitope) arose early whereas

ORGANISM(S): Homo sapiens

SUBMITTER: Susan Moir 

PROVIDER: E-GEOD-56499 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress