Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life

ABSTRACT: Neonates often generate incomplete immunity against intracellular pathogens, although the mechanism of this defect is poorly understood. An important question is whether the impaired development of memory CD8+ T cells in neonates is due to an immature priming environment or lymphocyte-intrinsic defects. Here we show that neonatal and adult CD8+ T cells adopted different fates when responding to equal amounts of stimulation in the same host. While adult CD8+ T cells differentiated into a heterogeneous pool of effector and memory cells, neonatal CD8+ T cells preferentially gave rise to short-lived effector cells and exhibited a distinct gene expression profile. Surprisingly, impaired neonatal memory formation was not due to a lack of responsiveness, but instead because neonatal CD8+ T ce

ORGANISM(S): Mus musculus

SUBMITTER: Andrew Grimson 

PROVIDER: E-GEOD-56575 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress