Ribosome profiling upon glucose starvation in S. cerevisiae

ABSTRACT: A universal feature of the response to stress and nutrient limitation is transcriptional upregulation of genes encoding proteins important for survival. Interestingly, under many of these conditions overall protein synthesis levels are reduced, thereby dampening the stress response at the level of protein expression. For example, during glucose starvation in yeast, translation is rapidly and reversibly repressed, yet transcription of many stress- and glucose-repressed genes is increased. Using ribosome profiling and microscopy, we found that this transcriptionally upregulated gene set consists of two classes: (1) one producing mRNAs that are preferentially translated during glucose limitation and are diffusely localized in the cytoplasm – this class includes many heat shock protein mRNAs;

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Brian Zid 

PROVIDER: E-GEOD-56622 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress