Endothelin-1 driven proliferation of PASMC is c-fos dependent

ABSTRACT: Background: Pulmonary hypertension is a rare disease characterized by pulmonary artery smooth muscle cell (PASMC) proliferation leading to vascularremodeling. Multiple factors have been associated with the vessel wall thickening. However, the responsible mechanisms are not fully understood. Aim: In this study we aim to decipher the role ofc-fos and c-jun transcription factors in the vascular remodeling process. Methods and Results: Expression and immunohistochemical analyses revealed high expression of c-fos and c-jun transcription factors in the vessel wall of lungs from human IPAH samples, hypoxia exposed mice and monocrotaline treated rats. Microarray study from hypoxic lung homogenates revealed MAP kinase asthe most differentially regulated pathway. Additionally, ET-1 and CTGF were the

ORGANISM(S): Mus musculus

SUBMITTER: Jochen Wilhelm 

PROVIDER: E-GEOD-56698 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress