Patterns of gene expression associated with recovery and injury in heat-stressed rats

ABSTRACT: Background: The in vivo gene response associated with hyperthermia and subsequent return to homeostasis or development of heat illness is poorly understood. Early activation of gene networks in the heat stress response is likely to lead to the systemic inflammation, multi-organ functional impairment, and other pathophysiological states characteristic of heat illness. Here, we perform an unbiased global characterization of the multi-organ gene response using an in vivo model of heat stress in the conscious rat. Results: Rats were subjected to elevated temperatures until implanted thermal probes indicated a maximal core temperature of 41.8 M-BM-0C (Tc,Max). Liver, lung, kidney, and heart were harvested at Tc,Max, 24 hours, and 48 hours after heat stress in groups of experimental animals and

ORGANISM(S): Rattus norvegicus

SUBMITTER: Christine Baer 

PROVIDER: E-GEOD-56740 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress