Unknown,Transcriptomics,Genomics,Proteomics

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Sorted Bulk and KK10-specific CD8+ T cells from HLA-B*2705 HIV chronic progressors before and after KK10 peptide stimulation

ABSTRACT: CD8+ T cells from HLA-B*2705 HIV+ chronic progressors Hi and Lo samples are CD8+ T cells bound by an HLA-B*2705 tetramer specific for the Gag p24 peptide KK10 PBMCs were incubated in the presence and absence of KK10 peptide for 6 days, and CD8+ and KK10-specific CD8+ T cell were sorted by flow cytometry

ORGANISM(S): Homo sapiens

SUBMITTER: Gaurav Gaiha 

PROVIDER: E-GEOD-56775 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Decreased HIV-specific CD8(+) T cell proliferation is a hallmark of chronic infection, but the mechanisms of decline are unclear. We analyzed gene expression profiles from antigen-stimulated HIV-specific CD8(+) T cells from patients with controlled and uncontrolled infection and identified caspase-8 as a correlate of dysfunctional CD8(+) T cell proliferation. Caspase-8 activity was upregulated in HIV-specific CD8(+) T cells from progressors and correlated positively with disease progression and  ...[more]