CD4+ T cell gene expression in virologically suppressed HIV-infected patients during Maraviroc intensification therapy.

ABSTRACT: Analysis of CD4+ T cell gene expression changes after 4 and 24 weeks of Maraviroc administration relative to baseline in 25 immunodiscordant patients with viral suppression. Maraviroc elicited very modest changes in CD4+ T cell transcriptome. The goal of this study was to identify genes with a potential role in Maraviroc-induced CD4+ T cell recovery in immunodiscordant patients. The study measured gene expression in CD4+ T cells isolated from the whole blood of HIV-infected patients before and at two time points after addition of Maraviroc to the baseline antiretroviral therapy. Thirty two patients were recruited from 3 sites, University of California, San Diego (UCSD), University of California, Los Angeles (UCLA) and University of Southern California (USC), and peripheral blood samples we

ORGANISM(S): Homo sapiens

SUBMITTER: Nadejda Beliakova-Bethell 

PROVIDER: E-GEOD-56804 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress