CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells

ABSTRACT: Intercellular communication is critical for integrating complex signals in multicellular eukaryotes. Vascular endothelial cells and T lymphocytes closely interact during the recirculation and trans-endothelial migration of T cells. In addition to direct cell-cell contact, we show that T cell derived extracellular vesicles can interact with endothelial cells and modulate their cellular functions. Thrombospondin-1 and its receptor CD47 are expressed on exosomes/ectosomes derived from T cells, and these extracellular vesicles are internalized and modulate signaling in both T cells and endothelial cells. Extracellular vesicles released from cells expressing or lacking CD47 differentially regulate activation of T cells induced by engaging the T cell receptor. Similarly, T cell-derived ext

ORGANISM(S): Homo sapiens

SUBMITTER: A Elkahloun 

PROVIDER: E-GEOD-56825 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress