Effects of dexamethasone on cultured lung explant

ABSTRACT: The lung is a branched tubular network with two distinct compartments — the proximal conducting airways and the peripheral gas exchange region — separated by a discrete boundary termed the bronchoalveolar duct junction (BADJ). Here we image the developing mouse lung in three-dimensions and show that two nested developmental waves demarcate the BADJ under the control of a global hormonal signal. A first wave of branching morphogenesis progresses throughout embryonic development, generating branches for both compartments. A second wave of conducting airway differentiation follows the first wave but terminates earlier, specifying the proximal compartment and setting the BADJ. The second wave is terminated by a glucocorticoid signaling: premature activation or loss of glucocorticoid signa

ORGANISM(S): Mus musculus

SUBMITTER: Jichao Chen 

PROVIDER: E-GEOD-56831 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress